Multi-dimensional imaging in early AMD

Dr Richard Unwin, Manchester University -£23,931

Early age-related macular degeneration (AMD) is closely linked to the switching on and off of the part of the immune system called the complement system. This system is genetically influenced and plays a key role in inflammation and defending against bacterial infections.

What is the problem?

The complement system consists of over 40 individual components. Currently, these components can only be studied separately in eye tissue, limiting our understanding of how they interact and contribute to AMD development.

What are they doing?

By use of a new technology called ‘imaging mass cytometry’ this project will develop a means of looking at several components together. The process involves binding a specific metal to an antibody. The antibody then bonds to its target, one of the molecules of the complement system. The exact positioning of the target molecule can be detected using a laser.